May 21, 2025 – COPENHAGEN – The Longevity Science Foundation (LSF), a nonprofit organization dedicated to funding research aimed at extending the healthy human lifespan, is proud to announce a grant award to the University of Copenhagen’s Department of Cellular and Molecular Medicine, for the study “Rejuvenating the Aging Brain.” The research is led by Dr. Morten Scheibye-Knudsen, a globally recognized expert in aging and neurodegeneration. The Foundation’s grant will fund a key project component over three years beginning in 2025.
The research aims to reverse brain aging by developing compounds that selectively eliminate senescent astrocytes, which are damaged brain cells that accumulate with age while preserving healthy neurons. These senescent cells are believed to contribute to cognitive decline and neurodegenerative diseases. Combining AI-driven screening with high-throughput compound testing, the research team will identify promising molecules, refine their specificity and pharmacokinetics, and validate their therapeutic potential through rigorous in vitro and in vivo testing.
The LSF’s support is essential in enabling this groundbreaking work, which could lead to the development of entirely new classes of treatments for age-related brain conditions. The project also reinforces the Foundation’s commitment to funding translational science that bridges the gap between laboratory discovery and real-world medical application.
“We are thrilled to support Dr. Morten Scheibye-Knudsen and his team at the University of Copenhagen,” said Joshua C. Herring, President and CEO of the Longevity Science Foundation. “This project reflects our belief that targeted, innovative research can lead to meaningful interventions in aging and neurodegeneration. We are committed to enabling discoveries that extend life and enhance its quality.”
This partnership is a step in achieving the Foundation’s broader mission of democratizing access to cutting-edge longevity research and ensuring that the most promising science receives the resources it needs to thrive.
If you are interested in supporting the groundbreaking research conducted by the Scheibye-Knudsen Lab, donating to the LSF, or supporting our other research initiatives, please reach out to our COO, Lev Dvornik, at ld@longevity.foundation, and our CEO, Joshua Herring, at jh@longevity.foundation. All donations are tax-deductible up to IRS limits and directly fund research, dollar for dollar.
About the Longevity Science Foundation
The Longevity Science Foundation (LSF) is a nonprofit organization advancing human longevity by funding research and development of medical technologies to extend the healthy human lifespan. The long-term mission of the Foundation is to prevent all chronic and age-related diseases and to help make longevity-focused care accessible to everyone, no matter their background, by bringing cutting-edge science on aging out of the laboratory and into the mainstream. To learn more, visit www.longevity.foundation.
Our work is made possible by our generous donors. To donate to the Longevity Science Foundation, visit https://longevity.foundation/support-us#donate.
Department of Cellular and Molecular Medicine, University of Copenhagen
The focus of the department is the functional cell, its genetic components and molecular cellular mechanisms in a medical context. With a firm foundation in the basic function of the normal and differentiating cell an understanding of the molecular, cellular and genetic mechanisms behind disease and aging is sought. Learn more at icmm.ku.dk.
The research aims to reverse brain aging by developing compounds that selectively eliminate senescent astrocytes, which are damaged brain cells that accumulate with age while preserving healthy neurons. These senescent cells are believed to contribute to cognitive decline and neurodegenerative diseases. Combining AI-driven screening with high-throughput compound testing, the research team will identify promising molecules, refine their specificity and pharmacokinetics, and validate their therapeutic potential through rigorous in vitro and in vivo testing.
The LSF’s support is essential in enabling this groundbreaking work, which could lead to the development of entirely new classes of treatments for age-related brain conditions. The project also reinforces the Foundation’s commitment to funding translational science that bridges the gap between laboratory discovery and real-world medical application.
“We are thrilled to support Dr. Morten Scheibye-Knudsen and his team at the University of Copenhagen,” said Joshua C. Herring, President and CEO of the Longevity Science Foundation. “This project reflects our belief that targeted, innovative research can lead to meaningful interventions in aging and neurodegeneration. We are committed to enabling discoveries that extend life and enhance its quality.”
This partnership is a step in achieving the Foundation’s broader mission of democratizing access to cutting-edge longevity research and ensuring that the most promising science receives the resources it needs to thrive.
If you are interested in supporting the groundbreaking research conducted by the Scheibye-Knudsen Lab, donating to the LSF, or supporting our other research initiatives, please reach out to our COO, Lev Dvornik, at ld@longevity.foundation, and our CEO, Joshua Herring, at jh@longevity.foundation. All donations are tax-deductible up to IRS limits and directly fund research, dollar for dollar.
About the Longevity Science Foundation
The Longevity Science Foundation (LSF) is a nonprofit organization advancing human longevity by funding research and development of medical technologies to extend the healthy human lifespan. The long-term mission of the Foundation is to prevent all chronic and age-related diseases and to help make longevity-focused care accessible to everyone, no matter their background, by bringing cutting-edge science on aging out of the laboratory and into the mainstream. To learn more, visit www.longevity.foundation.
Our work is made possible by our generous donors. To donate to the Longevity Science Foundation, visit https://longevity.foundation/support-us#donate.
Department of Cellular and Molecular Medicine, University of Copenhagen
The focus of the department is the functional cell, its genetic components and molecular cellular mechanisms in a medical context. With a firm foundation in the basic function of the normal and differentiating cell an understanding of the molecular, cellular and genetic mechanisms behind disease and aging is sought. Learn more at icmm.ku.dk.