Invested in Her — Longevity Science Foundation
Campaign Progress
$0 raised Goal: $250,000 · Sept 1, 2026 $25K Match Unlocked at Goal
Women-led research team
A Campaign for Women's Health & Longevity Research

Invested
in Her

Hundreds of millions of women live longer than men yet spend more years in poor health. The biology driving this disparity is rooted in ovarian aging and the menopausal transition, and it remains one of the most underfunded areas in medicine. We are raising $250,000 by September 1, 2026, to fund the science that closes that gap — for mothers, daughters, and women everywhere.

100% to Research
501(c)(3) · EIN 88-0936587
Tax-Deductible
Candid Seal of Transparency
~2×
higher mortality risk for women with early menopause (before 40) vs. typical timing
Source: Zhu et al., Human Reproduction, 2016
1 in 5
women develop Alzheimer's — double the rate of men
Driven by estrogen decline during the menopausal transition
2–4×
higher cardiometabolic risk after menopause, including hypertension and metabolic syndrome
Driven by estrogen decline, visceral fat increase, and insulin resistance
8.8%
of NIH Funding
Only 8.8% of NIH funding is directed to women's health research, and only a fraction of that studies ovarian aging and the menopausal transition. These are among the most underfunded areas in medicine, despite affecting hundreds of millions of women globally. The result: a critical biological transition remains insufficiently studied, limiting prevention, early intervention, and targeted treatment.
The Stakes

Menopause Is Not the End.
But It Changes Everything.

Women live longer than men on average, but spend more years in poor health. A single biological transition sits at the center of that disparity: menopause. The ovaries are among the fastest-aging organs in the body, and the hormonal cascade that follows their decline reverberates across every major system. The risks below are not incidental: they are downstream consequences of a process medicine has been chronically underprepared to address.

Cardiometabolic
2–4×
higher cardiometabolic risk after menopause
~3.5×increase in metabolic syndrome
~2×higher hypertension risk
~2×increase in coronary artery disease markers
Estrogen decline, visceral fat increase, insulin resistance
Brain Health
1 in 5
women develop Alzheimer's vs. 1 in 10 men
~2×higher lifetime risk of neurodegenerative disease
Earlier neurodegenerative changes linked directly to the menopausal transition
Skeletal Health
~5×
higher osteoporosis prevalence in women
1 in 5women over 50 affected vs. 1 in 20 men
=hip fracture mortality risk comparable to breast cancer
Rapid, sustained bone loss following estrogen decline
Early Menopause
~2×
higher mortality risk vs. typical menopause timing
#1fastest-aging organ in the body: the ovaries
For women with menopause before age 40, vs. typical onset — Zhu et al., Human Reproduction, 2016
The Systemic Gap

Medicine Was Built
on a Male Framework

The pervasive funding gap is a systemic symptom: for most of modern medical history, the female body was not the default. Women were excluded from research, undertested in clinical trials, and underrepresented in the data that shapes how disease is diagnosed and treated. The consequences of that exclusion are still being paid today.

1993
The year women were first federally mandated to be included in clinical trials

Prior to the NIH Revitalization Act, women were routinely excluded from research, leaving decades of drug dosages, diagnostic criteria, and treatment protocols calibrated entirely to male physiology.

Built-In Bias
The same disease can manifest entirely differently in women

Disease presentation, progression, and response to treatment often differ significantly between sexes. When research is built on male data, those differences go undetected, and women receive care designed for someone else's biology.

2014
The year the FDA first required sex-disaggregated data reporting in drug trials

For most of pharmaceutical history, drugs were approved without distinguishing how they perform across sexes. Women metabolize many drugs differently, yet dosing guidelines were written without them.

Our response

Fund the science to slow ovarian aging, delay menopause, and close the health gap it creates in women's lives.

Fund This Work
Our Approach

Women Lead Our
Scientific Work

Progress cannot rely on funding isolated therapies alone. We fund three coordinated pillars simultaneously — measurement, biological understanding, and early-stage intervention — targeting the full arc of women's reproductive aging. Our scientific leadership and advisory structure is led by women working at the frontier of this field.

"The science to close this gap exists. What's needed now is the commitment to fund it."

— Dr. Maria Corlianò, Head Scientific Analyst, LSF
Scientific Leadership
Dr. Maria Corlianò
Dr. Maria Corlianò
Head Scientific Analyst, Longevity Science Foundation
Full Bio →

Dr. Corlianò is a distinguished biologist with over eight years of preclinical and clinical research experience across leading institutions in Europe and Asia. A SINGA PhD scholar at the National University of Singapore and founder of OSbiome, she leads LSF's scientific evaluation, identifying high-impact projects in aging research and ensuring every funded initiative meets rigorous standards of scientific merit and translational potential.

Scientific Advisory Board
Evelyne Bischof, MD, PhD
Medical Director, Sheba Longevity Center
SAB Chair
Michael Levitt, PhD
Professor of Structural Biology, Stanford University
Nobel Prize in Chemistry
Eric Verdin, MD
President & CEO, Buck Institute for Research on Aging
Matt Kaeberlein, PhD
Professor of Genome Sciences, University of Washington
Andrea B. Maier, MD
Professor of Medicine, National University of Singapore
Alex Zhavoronkov, PhD
CEO & Founder, Insilico Medicine
What Your Money Does

Funding the Full Picture

Through our scientific review process, we have identified a portfolio of high-impact projects across all three pillars, ready for immediate funding. Click any pillar to explore the work.

Menopause is still diagnosed largely from symptoms and menstrual history — educated guesswork, not precision medicine. This work develops a "menopause clock" alongside non-invasive molecular sensors for real-time, cycle-by-cycle tracking of reproductive biomarkers. The goal: detect when a woman's biology begins to shift, early enough to act.

Developing tools to track ovarian aging with precision, not guesswork
Shifting diagnosis from symptom-based assessment to molecular monitoring
Building the measurement foundation on which targeted intervention can be constructed

These projects map the biological mechanisms connecting reproductive aging to broader systemic decline — in cognition, metabolism, and whole-body aging. This is the science of understanding the "why" before the "how to fix it."

Investigating the role of senescent cells in women's aging
Uncovering how estrogen disruption during menopause impacts brain circuitry and cognitive function
Identifying molecular and epigenetic mechanisms driving ovarian aging, toward therapies targeting the root cause

Rather than waiting for decline and treating downstream consequences, these projects target the biological source directly — representing a new frontier in treating reproductive aging as a modifiable condition, not a fixed fate.

Using gene therapy approaches to slow ovarian aging and delay menopause onset
Applying partial epigenetic reprogramming to restore youthful molecular signatures in aging ovarian tissue
Establishing the foundation for a new class of therapies to extend reproductive longevity

Transparency & Continuity

Every donor deserves to know exactly where their money goes and what it achieves. We commit to keeping you informed at every stage: from funds raised to research milestones.

Monthly Donor Updates

Every donor receives a monthly update on total funds raised and campaign progress — written in plain language, not jargon. You will always know where the campaign stands.

Research Progress Visibility

As funded projects hit key milestones — from study launch to interim findings to publication — we share those moments directly with the community that made them possible.

100% Allocation, Always

Every dollar donated goes directly to research. Our operating costs are funded separately — your gift is never diluted by overhead. This is a standing, unconditional commitment.

Your gift funds science across all three pillars simultaneously — at the early stage where targeted capital unlocks disproportionate progress.

Fund This Research
How to Help

More Ways to Help
Than Writing a Check

Women's health research has been underfunded for too long, and closing that gap requires more than institutional dollars. Whether you're in our network or finding us for the first time, there is a meaningful role for you in this campaign.

T
Treasure

Donate at whatever level resonates. 100% of every dollar goes directly to research — no overhead, no dilution.

T
Ties

Know someone who should be part of this? Make the introduction. A warm connection is often the highest-value contribution anyone can make.

T
Testimony

Share why women's health research matters to you. Personal stories move people in ways data alone cannot. Post, write, speak, and tag us.

T
Time

Follow our campaign and share our content throughout the quarter. Reach is everything in early momentum.

T
Talent

If you are a communicator, connector, or advocate who wants to play a more active role in this campaign, we want to hear from you.

Ready to give one of these? We'd love to connect.

info@longevity.foundation
Donor Tiers

Every Level
of Generosity

We partner with donors at every level, from first-time contributors to transformational funders who want to shape the future of longevity science. Each tier carries meaningful recognition and engagement.

View Donor Tiers

Transformational Gifts · $500K+

"Your legacy isn't just what you leave behind. It's what you set in motion."

— Joshua C. Herring, President & CEO, Longevity Science Foundation

The LSF Founders Fund offers named grant calls, first investment rights into research spinouts, co-investment alongside LongeVC, and a permanent place in the history of longevity science.

Speak With Our Team
Campaign closes September 1, 2026 · $250,000 goal

Women shouldn't have to
wait any longer. Let's get
fully invested in her.

The science exists. The projects are ready. What's needed now is the capital to put it in motion and the community of people who believe this work is long overdue.

501(c)(3) Verified EIN 88-0936587 Tax-Deductible 100% to Research