longevity.foundation 
University of Copenhagen Project: Rejuvenating the Aging Brain
Cellular senescence may contribute to the deterioration of brain tissue with age. The Longevity Science Foundation is funding research at the University of Copenhagen to clear these damaged cells, protect the brain, and stave off neurodegenerative diseases. Every dollar donated goes directly to the research.
www.longevity.foundation
Supporting Neurodegenerative Disease Prevention Research
More than 57 million people live with dementia worldwide, and Alzheimer's disease accounts for an estimated 60 to 70 percent of cases. These horrible diseases progressively damage the brain, affecting memory, thinking, and the ability to carry out everyday activities. Methods to effectively prevent or reverse the drivers of these diseases remain limited. During Alzheimer's Awareness Month, the Longevity Science Foundation is highlighting its support for research at the University of Copenhagen aimed at preventing and reversing this decline.
How Cellular Senescence May Contribute to Brain Aging
Cellular senescence occurs when damaged cells release inflammatory signals that affect and damage the surrounding tissue. As these senescent cells accumulate with age, they may serve as key catalysts for age-related disease. In the brain, our attention has focused on senescent astrocytes, the most abundant cells that maintain the environment in which neurons function, and are likely to cause widespread damage to cognitive function. Our aim is to support research uncovering how to selectively eliminate these cells and help preserve healthy brain tissue.
Rejuvenating the Aging Brain
Dr. Morten Scheibye-Knudsen and his team at the University of Copenhagen's Department of Cellular and Molecular Medicine are investigating exactly that, supported by a three-year grant awarded by the Longevity Science Foundation in May 2025. Their project quickly and effectively screens for compounds that selectively eliminate senescent astrocytes while preserving healthy neurons, then tests and refines the most promising candidates through cellular and preclinical studies.
Compounds that clear senescent cells have already reduced neuroinflammation and improved cognition in animal models of Alzheimer's. This is early-stage work, and considerable, though critical, research is needed to establish whether the approach is safe and effective in humans.
Fund the Science
This is the kind of science that struggles to find funding. It is too early for commercial investment, and philanthropic support is often what allows work like this to proceed.
Using the donation form on the right, making a charitable gift takes a few moments. You can elect to receive an automatically generated receipt sent to the email address you provide. Donations are processed securely with The Giving Block.
Our IRS Federal Tax ID (EIN) is 88-0936587. 100% of donations go directly to research, dollar for dollar.
To find out more about the Scheibye-Knudsen Lab and how to support it, write to info@longevity.foundation. We are always glad to explain the work in more detail, and how your support can move us one step closer to preventing or reversing neurodegeneration for all humankind.
A copy of the official registration and financial information may be obtained from the Division of Consumer Services by calling toll-free (800-435-7352) within the state. Registration does not imply endorsement, approval, or recommendation by the state. Florida state registration number: CH71052.
Donations can also be made by stock, donor-advised fund, cryptocurrency, qualified charitable distribution, or wire and check.